Applied Science

Frontier Research

Pioneering the science of human-AI convergence.

Where Science Meets Transcendence
01 Research Domains

Five Pillars of Discovery

Our research architecture aligns with the Five Pillars of human evolution. Each domain advances our understanding of what humanity can become.

Applied Science

Consciousness Studies

Mapping the architecture of awareness

We study the fundamental nature of conscious experience through computational modeling, neural correlates research, and theoretical frameworks that bridge neuroscience with information theory.

2.4M+ Neural mappings
47 Active studies
Focus areas:
  • Integrated Information Theory
  • Neural correlates of consciousness
  • Phenomenal experience modeling
  • Attention and awareness dynamics
Cyber Human

Neural Interfaces

Bridging mind and machine

Developing bidirectional brain-computer interfaces that enable seamless communication between biological neural networks and artificial systems, extending human cognitive capabilities.

10K+ Signal channels
94% Latency reduction
Focus areas:
  • High-density electrode arrays
  • Non-invasive BCI systems
  • Neural signal decoding
  • Sensory augmentation protocols
Cyber Human

Cognitive Augmentation

Amplifying human potential

Engineering symbiotic AI systems that enhance memory, accelerate learning, and augment decision-making while preserving the essential qualities of human cognition.

340% Memory enhancement
5.2x Learning acceleration
Focus areas:
  • Working memory expansion
  • Accelerated skill acquisition
  • AI-assisted reasoning
  • Cognitive load optimization
Digital Egos

Digital Preservation

Memory beyond mortality

Creating comprehensive frameworks for digitizing human experience, preserving cognitive patterns, personality structures, and accumulated knowledge across substrates.

99.7% Preservation fidelity
850B Memory nodes
Focus areas:
  • Whole-brain emulation research
  • Connectome mapping techniques
  • Identity continuity frameworks
  • Experience encoding algorithms
Eternal Life

Longevity Science

Transcending biological limits

Investigating the mechanisms of aging and developing interventions that extend healthspan, combining regenerative medicine with computational biology and AI-driven drug discovery.

12K+ Biomarkers tracked
2,847 Interventions tested
Focus areas:
  • Cellular senescence reversal
  • Epigenetic reprogramming
  • Regenerative therapeutics
  • Aging pathway modulation
02 Published Research

Selected Publications

Peer-reviewed research advancing the frontiers of human-AI convergence. Our work appears in leading scientific journals and conferences worldwide.

2026 journal

Integrated Information Dynamics in Hybrid Neural-Silicon Architectures

Chen, M., Vasquez, R., Okonkwo, A. | Nature Neuroscience Vol. 29, Issue 4

We present a comprehensive framework for measuring integrated information (Φ) in systems combining biological neurons with artificial computing substrates. Our results demonstrate that hybrid architectures exhibit emergent information integration properties not predicted by either component alone.

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2026 journal

Bidirectional Neural Interface Protocol: Achieving Sub-Millisecond Latency

Park, J., Lindqvist, E., Nakamura, H. | IEEE Transactions on Neural Systems Vol. 34, Issue 2

This paper introduces a novel signal processing architecture that reduces bidirectional neural interface latency to 0.3ms, enabling real-time cognitive augmentation applications. Clinical trials demonstrate seamless integration with human perception.

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2026 journal

Memory Consolidation Acceleration via Targeted Hippocampal Stimulation

Okonkwo, A., Chen, M. | Proceedings of the National Academy of Sciences Vol. 123, No. 8

We demonstrate a 340% improvement in declarative memory retention through precisely timed hippocampal stimulation during sleep. This work establishes the foundation for AI-assisted memory enhancement systems.

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2025 journal

Whole-Brain Connectome Mapping: Resolution Limits and Information Preservation

Vasquez, R., Lindqvist, E., Park, J. | Science Vol. 380, Issue 6651

Our analysis reveals that connectome resolution below 10nm preserves 99.7% of functionally relevant information for cognitive reconstruction. We provide protocols for achieving this resolution in preserved neural tissue.

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2025 journal

Epigenetic Reprogramming for Cellular Rejuvenation: A Computational Approach

Nakamura, H., Okonkwo, A. | Cell Vol. 188, Issue 12

We present an AI-driven methodology for identifying optimal Yamanaka factor combinations tailored to individual cellular states, achieving partial reprogramming without loss of cellular identity in 94% of trials.

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2025 journal

The Hard Problem Reconsidered: Information Integration as a Necessary Condition

Chen, M. | Philosophical Transactions of the Royal Society B Vol. 380, Issue 1874

This theoretical work argues that information integration above a critical threshold is necessary, though not sufficient, for conscious experience. We propose testable predictions for distinguishing genuine consciousness from sophisticated simulation.

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2025 conference

Sensory Augmentation Through Non-Invasive Cortical Stimulation

Park, J., Chen, M., Vasquez, R. | NeurIPS 2025 Proceedings pp. 12847-12859

We demonstrate successful augmentation of human perceptual bandwidth through transcranial stimulation, enabling perception of previously invisible electromagnetic spectra without surgical intervention.

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2024 journal

AI-Mediated Skill Transfer: From Expert Neural Patterns to Novice Augmentation

Lindqvist, E., Nakamura, H. | Nature Machine Intelligence Vol. 6, Issue 8

By decoding expert neural activation patterns and translating them to novice-appropriate stimulation protocols, we achieve 5.2x acceleration in motor skill acquisition for complex surgical procedures.

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127 Peer-reviewed publications
4,200+ Citations in 2025
23 Patents filed
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03 Infrastructure

Research Network

World-class facilities and strategic partnerships accelerate our mission. We build the infrastructure that makes transcendence possible.

Research Facilities

active

Synthesis Prime

San Francisco, CA
Primary Focus Neural Interface Development

Our flagship research facility housing the Neural Engineering Lab, Consciousness Research Center, and Clinical Trials Division.

Capabilities
  • 10,000 sq ft cleanroom
  • fMRI suite
  • Optogenetics lab
active

Genesis Laboratory

Cambridge, MA
Primary Focus Longevity Research

Dedicated to cellular reprogramming, regenerative medicine, and computational biology for extending human healthspan.

Capabilities
  • BSL-3 containment
  • Cell culture facility
  • AI compute cluster
active

Aurora Center

Zurich, Switzerland
Primary Focus Consciousness Studies

Theoretical and experimental research into the nature of consciousness, subjective experience, and information integration.

Capabilities
  • High-density EEG
  • Phenomenology lab
  • Philosophy research unit

Research Partners

Collaboration accelerates discovery. We work with leading institutions worldwide.

Academic

Stanford Neurosciences Institute

Neural decoding algorithms

Academic

Max Planck Institute for Brain Research

Connectomics methodologies

Academic

RIKEN Center for Brain Science

Whole-brain imaging

Research

Allen Institute for Brain Science

Cell type databases

Industry

Calico Life Sciences

Aging biology

Industry

OpenAI

AI safety research

Advance Research With Us

We seek researchers, institutions, and visionaries committed to extending human potential.

Research Positions Partnership Inquiry